You must be 18 years or older to enter the gaming floor at Little River Casino Resort. Watch us on Youtube.Little River Casino Resort in. Little River Casino Resort is owned and operated by the Little River Band of Ottawa Indians. 21 jobs.Manistee is in the northwest area of the Lower Peninsula and looks west onto Lake Michigan. Looking for live entertainment? We have that too, with nationally headlining musical and comedy acts performing regularly at our 1,600-seat event venue. During your stay, enjoy the suite of amenities we offer including indoor and outdoor pools, several restaurants, and our luxurious Nectar Spa & Salon. Additionally, our 95-space RV Park is ideal for travelers who love the open road. Little River Casino Resort, Orchard Highway, Manistee, MI, United States. Our lodge-style Manistee hotel features 292 well-appointed rooms inspired by our beautiful natural surroundings, offering guests the ultimate in comfort. Opened in 1999 with just 600 slot machines, our casino has grown to deliver an excellent gaming experience with over 1,100 slot and video poker machines, as well as dozens of table games, with new games being added all the time. Conveniently situated at the corner of the US31 and M22 in the charming town of Manistee, Little River Casino Resort is one of the most exciting entertainment destinations in northwest Michigan.